Related Experiment Video
Updated: Aug 21, 2026
09:04
In Vitro ELISA Test to Evaluate Rabies Vaccine Potency
Published on: May 11, 2020
Crimean-Congo hemorrhagic fever in Bulgaria
Anna Papa1, Iva Christova, Evangelia Papadimitriou
1WHO Collaborating Center for Reference and Research on Arboviruses and Haemorrhagic Fever Viruses at Aristotle University of Thessaloniki, Thessaloniki, Greece. annap@med.auth.gr
Emerging Infectious Diseases
|October 22, 2004
Insights
Epidemiologic features of Crimean-Congo hemorrhagic fever (CCHF) in Bulgaria were analyzed. The first genetic characterization of CCHF virus strains causing human disease in the country was performed.
Area of Science:
- Epidemiology
- Virology
- Public Health
Background:
- Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease with significant public health implications.
- Understanding the epidemiology and genetic diversity of CCHF virus is crucial for disease control.
Purpose of the Study:
- To describe the epidemiologic characteristics of CCHF cases in Bulgaria.
- To conduct the first genetic analysis of CCHF virus strains identified in Bulgaria between 2002 and 2003.
Main Methods:
- Retrospective analysis of CCHF case data.
- Molecular methods for viral RNA extraction, amplification, and sequencing.
Main Results:
- Detailed epidemiologic profile of CCHF patients in Bulgaria.
- Genetic sequencing data of circulating CCHF virus strains, providing insights into their origin and evolution.
Conclusions:
- The study provides essential baseline data on CCHF epidemiology in Bulgaria.
- Genetic characterization contributes to understanding CCHF virus diversity and transmission dynamics in the region.
Abstract:
We report the epidemiologic characteristics of Crimean-Congo hemorrhagic fever in Bulgaria, as well as the first genetic characterization of the virus strains circulating in the country in 2002 to 2003 that caused disease in humans.
More Related Videos
Related Concept Videos
01:26Rocky Mountain Spotted Fever
Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
01:27Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
01:27Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
01:18Yellow Fever
Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
01:25Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
01:18Viral Meningitis
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...