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Compatibility of sennoside A and B with pharmaceutical excipients
Q Verloop1, A F Marais, M M de Villiers
1Research Institute for Industrial Pharmacy, North-West University, Potchefstroom Campus, Potchefstroom, South Africa.
Abstract:
This study reports the incompatibility of sennoside A and B with the following commonly used pharmaceutical excipients: stearic acid, sodium carbonate, glucose, lactose, propyl paraben, sodium carbonate, stearic acid, citric acid, PEG, and sorbitol. Drug-excipient compatibility was tested using thermal (DSC) and analytical (HPLC) methods of analysis. Compatibility evaluation showed that dry powder mixtures could be used to formulate sennoside A and B products. However, when mixed with water--propyl paraben, sodium carbonate, stearic acid, citric acid, PEG, and sugar derivatives such as lactose, glucose and sorbitol--should not be used in sennoside containing products.
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