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Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
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Epstein-Barr virus nuclear antigen 2 induces interleukin-18 receptor expression in B cells

Franck Pagès1, Jérôme Galon, Galina Karaschuk

  • 1Institut National de la Santé et de la Recherche Médicale (INSERM) U255, Centre de Recherche Biomédicale des Cordeliers, Paris, France.

Blood
|October 23, 2004
PubMed

Epstein-Barr virus (EBV) latently infects and immortalizes B lymphocytes and causes lymphoproliferative malignancies. We show here that the EBV nuclear antigen EBNA2 induces expression of the 2 chains of the interleukin-18 receptor (IL-18R) in Burkitt lymphoma (BL) cell lines and in nontransformed B cells. Activation of IL-18R expression by EBNA2 is independent of its interaction with the transcriptional repressor RBPJ kappa. It occurs in the absence of any other viral protein but requires de novo synthesis of cellular proteins. IL-18R induction is a highly specific function of EBNA2, because neither other EBV latent proteins nor the cellular proteins c-myc or Notch can exert this effect. Using cDNA microarray expression profiling, we find that the IL-18 receptor expressed in EBV-infected BL cells has signaling capacity, because IL-18 significantly modified gene expression. We report that EBNA2 expression is associated with IL-18R expression in vivo in EBV-positive B-lymphomas from AIDS patients.

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