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Protective effect of phenyl-t-butylnitrone in rats with focal cerebral ischemia
O V Povarova1, A A Timoshin, O S Medvedev
1Department of Pharmacology, Faculty of Fundamental Medicine, M V Lomonosov Moscow State University, Moscow. povarova@fbm.msu.ru
Abstract:
Phenyl-t-butylnitrone produces a potent neuroprotective effect in rats with focal cerebral ischemia modeled by distal occlusion of the middle cerebral artery. The infarction area markedly decreased after treatment with phenyl-t-butylnitrone. The content of phenyl-t-butylnitrone in the brain, liver, and kidneys was measured by the method of electron paramagnetic resonance.
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