Related Experiment Video

Updated: Jul 31, 2026

Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice
05:08

Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice

Published on: October 3, 2019

Heart rate variations during isoproterenol infusion in congestive heart failure: relationships to cardiac mortality

B Brembilla-Perrot1

  • 1CHU Brabois, Vandoeuvre Les Nancy, France.

American Heart Journal
|April 1, 1992
PubMed

Insights

Assessing heart rate modulation with isoproterenol infusion can predict cardiac death risk in severe heart failure patients. A weak heart rate increase indicates a poor prognosis and high risk of mortality from heart failure.

Area of Science:

  • Cardiology
  • Heart Failure Research
  • Autonomic Nervous System Function

Background:

  • Severe cardiac heart failure (CHF) is associated with significant heart rate modulation abnormalities.
  • Understanding these abnormalities is crucial for predicting patient outcomes.

Purpose of the Study:

  • To correlate variations in sinus cycle length (SCL) during low-dose isoproterenol infusion with prognosis in CHF patients.
  • To identify predictive markers for mortality in severe cardiac heart failure.

Main Methods:

  • Infusion of low-dose isoproterenol (4 micrograms/min) in 83 severe CHF patients.
  • Measurement of sinus cycle length (SCL) variations.
  • Correlation of SCL changes with patient outcomes over a mean follow-up of 28 months.

Main Results:

  • Patients who died from CHF (Group I) exhibited significantly weaker ejection fraction, smaller baseline SCL, and a reduced SCL shortening percentage during isoproterenol infusion compared to survivors (Group III) and those who died suddenly (Group II).
  • A SCL shortening percentage ≤15% during isoproterenol infusion demonstrated high sensitivity (89%) and specificity (93%) for predicting death from CHF.
  • Lower ejection fraction and reduced SCL shortening are associated with increased mortality risk in severe CHF.

Conclusions:

  • Low-dose isoproterenol infusion can serve as a valuable tool for assessing prognosis in severe cardiac heart failure.
  • A diminished heart rate response to isoproterenol infusion is a significant indicator of poor prognosis and elevated risk of cardiac death in CHF patients.

More Related Videos

Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis08:05

Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis

Published on: May 19, 2021

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models07:49

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models

Published on: July 21, 2023

Related Concept Videos

Increased pulse rate01:17

Increased pulse rate

Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues.
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
Factors Influencing Heart Rate01:30

Factors Influencing Heart Rate

The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart rate...
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...