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Updated: Aug 21, 2026

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification
Published on: July 25, 2025
[Management of sevoflurane anesthesia for a patient with multiple drug allergies]
Motohiro Nakamura1, Kouichiro Minami, Koji Hara
1Department of Anesthesiology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu 807-8555.
Abstract:
There have been several reports on anesthesia for a patient with a history of multiple drug allergies. We present here anesthesia for a 33-year-old woman with histories of multiple drug allergies. She was scheduled to undergo total abdominal hysterectomy. We could not perform preoperative screening of the drugs using a dermal test because of a high risk of anaphylactic shock. Anesthesia was induced and maintained with sevoflurane and nitric oxide. The operation was finished without complications and her postoperative course was uneventful. It is important preoperatively to obtain histories of allergies adequately for recognition of allergens.
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