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Serum levels of angiogenic cytokines decrease after antineoplastic radiotherapy.

Roberto Ria1, Maurizio Portaluri, Francesca Russo

  • 1Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari, Policlinico, Piazza Giulio Cesare 11, I-70124 Bari, Italy.

Cancer Letters
|October 27, 2004
PubMed
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Serum levels of key angiogenic cytokines, including fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF), decrease post-radiotherapy. This reduction correlates with radiation dose and treatment response in cancer patients.

Area of Science:

  • Oncology
  • Radiotherapy Research
  • Cancer Biomarkers

Background:

  • Angiogenic cytokines play a crucial role in cancer progression and response to therapy.
  • Radiotherapy is a cornerstone treatment for many cancer types.
  • Changes in serum angiogenic cytokine levels after radiotherapy may indicate treatment efficacy.

Purpose of the Study:

  • To investigate the changes in serum levels of fibroblast growth factor-2 (FGF-2), vascular endothelial growth factor (VEGF), and hepatocyte growth factor (HGF) after radiotherapy.
  • To determine if these changes correlate with radiation dose, tumor type, patient age, and hemoglobin levels.
  • To assess the relationship between cytokine level diminution and treatment response or progression-free survival.

Main Methods:

  • Serum samples were collected from cancer patients before and after radiotherapy across various tumor types.

Related Experiment Videos

  • Quantification of soluble FGF-2, VEGF, and HGF levels was performed using appropriate assays.
  • Statistical analysis was employed to evaluate changes in cytokine levels and their correlations with clinical parameters.

    • Main Results:

    • Serum levels of FGF-2 and VEGF significantly decreased following radiotherapy.
    • Hepatocyte growth factor (HGF) levels did not show a significant decrease.
    • The extent of FGF-2 and VEGF reduction was found to be related to the radiation dose administered and the patient's response to treatment.

    Conclusions:

    • Radiotherapy leads to a significant decrease in serum FGF-2 and VEGF levels in cancer patients.
    • The observed diminution of these angiogenic factors is dose-dependent and associated with treatment outcomes.
    • FGF-2 and VEGF may serve as potential biomarkers for monitoring radiotherapy response.