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Decrease of immobility behavior in forced-swimming test and immune system enhancing effect of traditional medicine
Hye-Young Shin1, Tae-Yong Shin, Sang-Wan Seo
1College of Oriental Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemun-Gu, Seoul, 130-701, Republic of Korea.
Pharmacology, Biochemistry, and Behavior
|October 27, 2004
Summary
Gamisipjundaebo-tang (GSDBT) enhances physical strength and immune function. This study found GSDBT reduces fatigue and boosts key immune indicators like interferon-gamma and interleukin-2.
Area of Science:
- Traditional Korean Medicine
- Immunology
- Biochemistry
Background:
- Gamisipjundaebo-tang (GSDBT) is traditionally used to improve physical strength.
- The scientific basis for its immune-enhancing and anti-fatigue effects requires further investigation.
Purpose of the Study:
- To evaluate the immune-enhancing effects of GSDBT.
- To assess the anti-fatigue properties of GSDBT through physiological and biochemical markers.
Main Methods:
- Mice were administered GSDBT (0.1 and 1 g/kg) orally for 14 days.
- Forced-swimming tests and analysis of blood biochemical parameters (glucose, BUN, LDH, CK, total protein) were conducted.
- Cytokine production (IFN-γ, IL-2, IL-4) and protein expression in MOLT-4 cells and splenocytes were measured.
Main Results:
- GSDBT significantly reduced immobility time in the forced-swimming test, indicating anti-fatigue effects.
- Blood glucose and lactate dehydrogenase levels increased, while blood urea nitrogen decreased with GSDBT administration.
- GSDBT significantly increased interferon (IFN)-gamma and interleukin (IL)-2 levels, and IFN-gamma protein expression in immune cells.
Conclusions:
- GSDBT demonstrates significant anti-fatigue properties.
- GSDBT possesses immune-enhancing capabilities, particularly by increasing IFN-γ and IL-2 production.
- These findings suggest GSDBT could be beneficial for immune function improvement and combating fatigue.