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Updated: Aug 21, 2026

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In Vitro Biochemical Assays using Biotin Labels to Study Protein-Nucleic Acid Interactions
Published on: July 17, 2019
Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically
Hajime Motoyoshi1, Masato Horigome, Ken Ishigami
1Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Bioscience, Biotechnology, and Biochemistry
|October 27, 2004
Abstract:
The structure-activity relationship for FR901464, a potent cell-cycle inhibitor, was examined by synthesizing its analogs. A versatile method for converting FR901464 was devised. This method made it possible to synthesize biologically active FR901464-biotin conjugates which could be used to isolate the binding proteins.

