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Diagnosis of sickle cell disease in chronically transfused patients

D R Oliveri1, C L Ober, A L Horwitz

  • 1Department of Obstetrics and Gynecology, University of Chicago, Illinois 60637.

The American Journal of Pediatric Hematology/Oncology
|January 1, 1992
PubMed

Standard electrophoretic methods for the diagnosis of hemoglobinopathies are confounded in individuals chronically transfused. We present the accurate diagnosis of sickle cell disease in two such transfused patients by the application of polymerase chain reaction technology to analyze patient's hemoglobin beta-chain genes directly.

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