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Updated: Aug 21, 2026
Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
Published on: December 18, 2016
Effective blood signal suppression using double inversion-recovery and slice reordering for multislice fast spin-echo
Hideto Kuribayashi1, Jean J Tessier, David R Checkley
1AstraZeneca, Global Sciences and Information, Alderley Park, Macclesfield, Cheshire, UK. hideto.kuribayashi@astrazeneca.com
Purpose:
To design a multislice double inversion-recovery fast spin-echo (FSE) sequence, with k-space reordered by inversion time at slice position (KRISP) technique, to produce black-blood vessel wall magnetic resonance imaging (MRI).
Materials And Methods:
In this sequence, central k-space sampling for each slice is required at inversion time (TI) of the blood signal. To fill the entire k-space, the peripheral lines are obtained less or greater the TI and using a rotating slice order. Blood flow signal suppression was first evaluated using a phantom. Simulation studies were used to investigate FSE image quality. The final sequence was then applied to the rabbit abdominal aorta MRI at 4.7 T.
Results:
In the flow phantom study, artifacts from slow-flowing water were substantially reduced by the KRISP technique; residual water spins were dephased by the strong phase-encoding gradient required for peripheral k-space. These dephased spins flowed into the slice plane where the center of k-space was being acquired at the TI of the flowing water signal. Multislice black-blood MR images were successfully obtained in the rabbit abdomen using the sequence with the k-trajectory optimized by the simulation study.
Conclusion:
The KRISP technique was effective both in multislice double inversion-recovery FSE and in blood signal suppression.
Insights
The KRISP technique effectively suppresses blood signals in multislice double inversion-recovery fast spin-echo MRI. This advancement enables clearer black-blood vessel wall imaging, reducing artifacts in magnetic resonance imaging.
Area of Science:
- Medical Imaging
- Magnetic Resonance Imaging (MRI)
- Cardiovascular Imaging
Background:
- Black-blood imaging is crucial for visualizing vessel walls.
- Traditional methods face challenges with blood flow artifacts.
- Optimizing fast spin-echo (FSE) sequences is key for efficient imaging.
Purpose of the Study:
- To develop a multislice double inversion-recovery FSE sequence using the KRISP technique.
- The goal was to achieve effective black-blood vessel wall MRI.
- To suppress blood flow signals for improved image quality.
Main Methods:
- Implemented the k-space reordered by inversion time at slice position (KRISP) technique.
- Utilized central k-space sampling at specific inversion times (TI).
- Evaluated signal suppression in phantoms, simulations, and rabbit aorta MRI at 4.7 T.
Main Results:
- The KRISP technique significantly reduced artifacts from slow-flowing water in phantom studies.
- Dephased spins were directed away from the central k-space acquisition.
- Successful multislice black-blood MR images of rabbit abdominal aorta were acquired.
Conclusions:
- The KRISP technique proved effective for multislice double inversion-recovery FSE.
- This method successfully achieved blood signal suppression.
- The developed sequence enhances black-blood vessel wall imaging capabilities.
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