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Updated: Aug 21, 2026

Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease
Published on: February 9, 2016
[Mechanisms of muscovite on gastric mucosal protective effect]
Yun Qian1, Jian-Min Si, Liang-Jing Wang
1Gastroenterology Laboratory of Sir Run Run Shaw Clinic Medical Center, Zhejiang University, Hangzhou 310016, China.
Objective:
To explore the mechanisms of muscovite gastric mucosal protective effect.
Method:
Rat model of chronic gastritis were used. After gastric mucosal injury was induced, the rats were divided into 6 groups and were treated with different drugs. 2 weeks later, the tissue and blood samples were obtained and measured.
Result:
The general conditions, the observations under macroscopy, microscope and electron microscope of the middle and high dose of muscovite groups resembled those of the normal group. Their PH levels were higher than those of the model group, and the rates of intestinal metaplasia were lower, but the PGE2 level of the middle dose of muscovite group was the highest.
Conclusion:
Muscovite can be adsorbed on the surface of the gastric mucosa. It has gastric mucosal protective effect by improving excretion of mucus and synthesis of PGE2 in gastric mucosa, restraining gastric acid, reversing of intestinal metaplasia and decreasing inflammation cells.
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