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[Study rat nephrotoxicity of Longdan Xiegan Tang]
Qing Fang1, Xiao-Ping Zhan, Jian-Ling Mo
1Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China. pharmacy302@sohu.com
Objective:
To investigate the nephrotoxocity of Longdan Xiegan Tang in rats, and to test its safety.
Method:
Sprague-Dauley rats were given Longdan Xiegan Tang 4.5 mL x (100 mg)(-1) Bid for thirty days, and the control group was given NS. MTP, BUN, Cr, MDA, MTP/Ucr and SOD were measured on 1st, 2nd, 3rd, 4th week. The kidney tissues were viewed with light microscopy and electron microscope.
Result:
MTP and MTP/Ucr were obviously higher than controls ( P < 0.01), and the other index had no difference (P > 0.05). No remarkable structural change could been seen with light microscopy, but with electron microscope we could find that the basal membranes were thickened and some of foot process were infused.
Conclusion:
Longdan Xiegan Tang will result in injury of kidney function.
