Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ketogenic diets and physical performance.

Stephen D Phinney1

  • 16108 Boothbay Court, Elk Grove, CA 95758, United States of America. sdphtb@earthlink.net.

Nutrition & Metabolism
|October 28, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Broad-Spectrum Effects of Carbohydrate Reduction on Inflammatory and Immune Mediators in Type 2 Diabetes.

Endocrine research·2026
Same author

Effects of a continuous remote care intervention including nutritional ketosis on kidney function and inflammation in adults with type 2 diabetes: a <i>post-hoc</i> latent class trajectory analysis.

Frontiers in nutrition·2025
Same author

5-Year effects of a novel continuous remote care model with carbohydrate-restricted nutrition therapy including nutritional ketosis in type 2 diabetes: An extension study.

Diabetes research and clinical practice·2024
Same author

Expert consensus on nutrition and lower-carbohydrate diets: An evidence- and equity-based approach to dietary guidance.

Frontiers in nutrition·2024
Same author

Impact of the COVID-19 Pandemic on the Effectiveness of a Metabolic Health Telemedicine Intervention for Weight Loss: A Propensity Score Matching Analysis.

Frontiers in public health·2022
Same author

Continuous care intervention with carbohydrate restriction improves physical function of the knees among patients with type 2 diabetes: a non-randomized study.

BMC musculoskeletal disorders·2022
Same journal

Integrated serum and fecal metabolomics identifies compartment-specific metabolic remodeling in mice fed high-fat and Western diets.

Nutrition & metabolism·2026
Same journal

Prebiotic xylo-oligosaccharides cause modest taxonomic shifts in the gut microbiota but do not increase insulin sensitivity in insulin resistant individuals.

Nutrition & metabolism·2026
Same journal

Response of FTO gene polymorphisms to continuous caloric restriction diets on lipid and glycemic biomarkers in overweight and obese adults: a systematic review and meta-analysis.

Nutrition & metabolism·2026
Same journal

Vitamin E administration reduces liver enzyme levels in patients with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD): evidence from a systematic review and meta-analysis.

Nutrition & metabolism·2026
Same journal

Impact of L-carnitine supplementation on lipid profile parameters in overweight and obese women: a systematic review and meta-analysis of randomized controlled trials.

Nutrition & metabolism·2026
Same journal

Exosomal miRNA-714 derived from adipose tissue macrophages regulates adipocyte glucose and lipid metabolism via IGF1R targeting.

Nutrition & metabolism·2026
See all related articles

Low carbohydrate diets can impair physical performance, but adaptation is possible. Traditional Inuit practices show that adequate electrolytes and moderate protein intake (15-25%) enable endurance despite nutritional ketosis.

Area of Science:

  • Nutritional Science
  • Exercise Physiology
  • Human Adaptation

Background:

  • Low carbohydrate diets are often associated with impaired physical performance.
  • Nutritional ketosis, a metabolic state induced by carbohydrate restriction, can affect energy availability.
  • Understanding human adaptation to altered macronutrient intake is crucial for optimizing performance.

Purpose of the Study:

  • To investigate the factors enabling unimpaired endurance performance on a low carbohydrate diet.
  • To explore traditional dietary strategies that mitigate potential negative effects of carbohydrate restriction.

Main Methods:

  • Analysis of traditional Inuit dietary practices and their implications for metabolic adaptation.
  • Review of physiological requirements for endurance performance under nutritional ketosis.

Related Experiment Videos

Main Results:

  • Impaired physical performance is not an obligatory outcome of low carbohydrate diets.
  • Sufficient adaptation time, optimized sodium and potassium intake, and protein intake between 15-25% of energy expenditure are key.
  • These factors allow for unimpaired endurance performance even during nutritional ketosis.

Conclusions:

  • Traditional Inuit dietary principles offer a model for adapting to low carbohydrate intake.
  • Strategic nutritional management, including electrolyte balance and controlled protein intake, can support endurance performance in nutritional ketosis.