Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Atherosclerosis: immunopathogenesis and immunotherapy.

Ryuji Ohashi¹, Hong Mu, Qizhi Yao

¹Molecular Surgeon Research Center, Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Texas 77030, USA.

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

|October 28, 2004

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Genome-Wide Association Study and Genomic Prediction for Maximum Litter Size in Sows.

Animal genetics·2026

Same author

Integrated multi-population selection-signature scans identify putative functional genes influencing litter size in jishen black pigs.

BMC genomics·2026

Same author

Genome-Wide Association Study Revealed Key Genes with the Teat Number in Jishen Black Pigs.

Veterinary sciences·2026

Same author

Pan-genome insights into genetic diversity, evolutionary dynamics, and pathogenic traits of Staphylococcus agnetis.

BMC genomics·2026

Same author

Axin1 Suppresses Muscle Regeneration by Promoting Myoblast Proliferation and Inhibiting Differentiation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026

Same author

Short-term and lagged effects of ambient air pollution on emergency visits for cardiovascular diseases modified by meteorological factors.

International journal of hygiene and environmental health·2026

Immune responses, involving cells like macrophages and T cells, are key drivers of atherosclerosis. Modulating these immune responses offers a promising new strategy for treating cardiovascular complications.

Area of Science:

Immunology
Cardiovascular Medicine
Pathology

Background:

Atherosclerosis is a chronic cardiovascular disease with complex mechanisms.
Genetic and lifestyle factors influence its initiation and progression.
Cellular and humoral immunity are increasingly recognized as critical contributors to atherogenesis.

Purpose of the Study:

To elucidate the role of immune system components in atherosclerosis.
To explore immunomodulatory strategies for treating atherosclerosis.
To investigate the impact of infections on atherosclerosis development.

Main Methods:

Utilized mouse models with genetic modifications of the immune system.
Investigated the effects of blocking macrophage-related factors and scavenger receptors (SR-A, CD36).

Related Experiment Videos

Examined the impact of shifting CD4+ T cell responses from Th1 to Th2 and the role of anti-inflammatory cytokine IL-10.

Assessed the influence of microbial and viral eradication on atherosclerosis.

Main Results:

Inhibition of atherosclerosis progression observed by blocking macrophage factors and scavenger receptors.
A shift from Th1 to Th2 CD4+ T cell immunity led to reduced atherosclerotic lesions via IL-10 secretion.
Eradication of microbial and viral infections decreased atherosclerosis.
Immune responses, including macrophages, T cells, and dendritic cells, alongside autoantigens like heat shock protein (HSP 60/65) and oxidized LDL, are implicated in lesion formation.

Conclusions:

Immune responses are fundamental mechanisms underlying atherosclerosis.
Immunomodulation presents a viable therapeutic strategy for atherosclerosis.
Targeting immune pathways offers potential for novel cardiovascular treatments.