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Published on: May 1, 2015
WHO reclassification of breast lymphomas
M B Loughrey1, P Windrum, M A Catherwood
1Department of Pathology, Belfast City Hospital, Belfast BT9 7AB, Northern Ireland, UK.
Journal of Clinical Pathology
|October 29, 2004
Summary
This study reclassified 14 breast lymphoma cases using World Health Organization criteria. All identified breast lymphomas were of B cell origin, with primary cases being more common and predominantly diffuse large B cell lymphomas.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Breast lymphoma is a rare malignancy.
- Accurate classification is crucial for prognosis and treatment.
Purpose of the Study:
- To reclassify 14 historical breast lymphoma cases using current World Health Organization (WHO) criteria.
- To analyze the characteristics and origins of primary and secondary breast lymphomas.
Main Methods:
- Retrospective review of 14 breast lymphoma cases diagnosed between 1990 and 2004.
- Reclassification of all cases based on the World Health Organization (WHO) classification system for lymphoid neoplasms.
Main Results:
- All 14 cases were confirmed as B-cell lymphomas.
- Primary breast lymphomas were more frequent than secondary cases.
- Diffuse large B-cell lymphoma was the predominant type among primary cases.
- Secondary breast lymphomas exhibited greater heterogeneity in subtypes.
- Secondary cases were associated with a poorer prognosis.
Conclusions:
- Reclassification using WHO criteria refined the understanding of breast lymphoma subtypes.
- B-cell origin is characteristic of breast lymphomas.
- Primary breast lymphomas, often diffuse large B-cell lymphomas, present differently from secondary types.
- The heterogeneity and poor prognosis of secondary breast lymphomas warrant further investigation.
