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Related Experiment Videos

Mapping dopamine function in primates using pharmacologic magnetic resonance imaging.

Bruce G Jenkins1, Rosario Sanchez-Pernaute, Anna-Liisa Brownell

  • 1Massachusetts General Hospital (MGH) Nuclear Magnetic Resonance Center, Athinoula A. Martinos Center for Biomedical Imaging, Boston, Massachusetts 02129, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|October 29, 2004
PubMed
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Pharmacologic MRI (phMRI) effectively maps dopamine circuits in primates. Parkinsonian primates show reduced amphetamine response, highlighting phMRI

Area of Science:

  • Neuroscience
  • Pharmacology
  • Medical Imaging

Background:

  • Dopamine (DA) receptors are crucial in neurological and psychiatric disorders like Parkinson's disease, schizophrenia, and drug abuse.
  • Understanding DA circuitry dynamics is vital for diagnosing and treating these conditions.

Purpose of the Study:

  • To map dopamine-associated brain circuitry in nonhuman primates using pharmacologic magnetic resonance imaging (phMRI).
  • To investigate changes in DA circuitry in a primate model of Parkinson's disease.
  • To assess the utility of phMRI in evaluating functional DA pathways.

Main Methods:

  • Utilized amphetamine challenge combined with phMRI in control and MPTP-treated parkinsonian cynomolgous monkeys.
  • Longitudinal study incorporating positron emission tomography (PET) for dopamine transporter imaging.

Related Experiment Videos

  • Measured relative cerebral blood volume (rCBV) changes in response to amphetamine.

    • Main Results:

    • Amphetamine increased rCBV in novel regions like the parafascicular thalamus and dentate nucleus, and known areas including the substantia nigra and nucleus accumbens in controls.
    • Parkinsonian primates exhibited a blunted response to amphetamine, with relative preservation in the nucleus accumbens and parafascicular thalamus.
    • Significant correlation found between rCBV loss in the substantia nigra, PET-assessed dopamine transporters, and behavioral measures.
    • Premotor and motor cortex recruitment observed in lesioned monkeys post-amphetamine, mirroring Parkinson's patient responses.

    Conclusions:

    • phMRI is a highly sensitive and spatially resolved tool for assessing dynamic changes in primate DA brain circuitry.
    • phMRI can differentiate between normal and dysfunctional DA pathways, offering insights into Parkinson's disease.
    • The study validates phMRI as a powerful method for preclinical research in DA-related disorders.