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Related Experiment Videos

Coccidioidomycosis causing massive cervical lymphadenopathy.

Jason A Biller1, Michael C Scheuller, David W Eisele

  • 1Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA 94143, USA. jasonbiller@yahoo.com

The Laryngoscope
|October 29, 2004
PubMed
Summary

Coccidioidomycosis, a fungal infection, rarely affects the head and neck. This case highlights that combining needle aspiration with antifungal medication improved treatment for disseminated coccidioidomycosis with lymphadenopathy.

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Area of Science:

  • Infectious Diseases
  • Mycology
  • Head and Neck Surgery

Background:

  • Coccidioidomycosis is a fungal infection endemic to the southwestern United States.
  • Head and neck involvement is rare, often presenting a diagnostic challenge.
  • Disseminated disease requires prompt and effective management.

Observation:

  • A patient presented with disseminated coccidioidomycosis and massive submandibular cystic lymphadenopathy.
  • The condition was unresponsive to standard systemic antifungal therapy.
  • Cystic lymphadenopathy indicated significant fungal burden in the head and neck region.

Findings:

  • Concomitant needle aspiration of cystic lymph nodes significantly reduced fungal load.
  • Modification of systemic antifungal medication, alongside aspiration, led to clinical improvement.

Related Experiment Videos

  • This combined approach demonstrated enhanced efficacy over antifungal therapy alone.

    • Implications:

    • Needle aspiration can be a valuable adjunctive therapy for managing localized fungal burdens in disseminated coccidioidomycosis.
    • Aggressive management strategies may be necessary for refractory head and neck coccidioidomycosis.
    • Further research into multimodal treatment approaches for disseminated fungal infections is warranted.