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[Extrapleural pneumonectomy for malignant pleural mesothelioma]
Yoshio Hosokawa1, S Matsuge, K Hayashi
1Department of Surgery, Kin-ikyo Chuo Hospital, Sapporo, Japan.
Kyobu Geka. the Japanese Journal of Thoracic Surgery
|October 30, 2004
Summary
Extrapleural pneumonectomy (EPP) shows variable outcomes for malignant pleural mesothelioma (MPM). Epithelial MPM cases had better prognoses than biphasic, but further trials are needed to confirm EPP efficacy.
Area of Science:
- Thoracic surgery
- Oncology
- Pulmonology
Context:
- Malignant pleural mesothelioma (MPM) lacks a definitive standard treatment.
- Extrapleural pneumonectomy (EPP) is considered a primary surgical option for epithelial MPM, despite potential severe complications.
Purpose:
- To report outcomes of five patients with MPM who underwent EPP.
- To evaluate the efficacy and complications of EPP in MPM treatment.
Summary:
- Five MPM patients underwent EPP between 1988-2003. Histological subtypes influenced outcomes: biphasic MPM cases experienced fatal complications (respiratory failure, empyema). Epithelial MPM cases showed varied results, with two surviving long-term without recurrence and one succumbing to complications post-radiotherapy.
Impact:
- This case series suggests that EPP outcomes for MPM may differ based on histological subtype.
- Highlights the need for more extensive research, including randomized controlled trials, to establish the definitive role and safety of EPP in MPM management.