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A Murine Orthotopic Bladder Tumor Model and Tumor Detection System
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Primary Lymphangiosarcoma of the Urinary Bladder in a Dog
M Michishita1, Y Ishizaki1, M Konnai1
1Department of Veterinary Pathology, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
Journal of Comparative Pathology
|September 22, 2020
Summary
This study reports the first canine bladder lymphangiosarcoma in a toy poodle. Diagnostic imaging and immunohistochemistry confirmed this rare tumor, highlighting its unique presentation and characteristics.
Area of Science:
- Veterinary Pathology
- Canine Oncology
- Surgical Pathology
Background:
- Lymphangiosarcoma is a rare malignant tumor originating from lymphatic endothelial cells.
- Primary bladder tumors are uncommon in dogs, with various histological types reported.
- This case presents a unique instance of lymphangiosarcoma in the canine bladder.
Observation:
- A 12-year-old toy poodle presented with a 2 cm bladder apex mass.
- Imaging revealed a firm, hemorrhagic mass with specific ultrasonographic and CT findings.
- Histopathology showed neoplastic cells invading muscle and extra-muscular layers.
Findings:
- Immunohistochemistry confirmed neoplastic cells positive for vimentin and LYVE-1.
- The tumor cells were negative for cytokeratin, factor VIII, CD31, CD34, Prox-1, S100, desmin, α-smooth muscle actin, and MyoD1.
- Absence of basal lamina was supported by negative laminin staining and ultrastructural examination, confirming lymphangiosarcoma.
Implications:
- This is the first documented case of canine urinary bladder lymphangiosarcoma.
- The findings contribute to understanding rare tumor types in veterinary oncology.
- Further research may elucidate the pathogenesis and treatment of this rare condition.
