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Related Experiment Videos

Re-evaluation of plasma creatinine concentration in normal pregnancy.

J C Girling1

  • 1West Middlesex University Hospital, Isleworth, UK.

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
|October 30, 2004
PubMed
Summary

Establishing new reference ranges for plasma creatinine during pregnancy is crucial for accurate clinical assessment. This study defines trimester-specific upper limits, aiding in the early detection of renal dysfunction in pregnant individuals.

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Area of Science:

  • Obstetrics and Gynecology
  • Nephrology
  • Clinical Biochemistry

Background:

  • Pregnancy is associated with physiological changes in renal function, typically leading to decreased plasma creatinine levels.
  • Existing data on creatinine concentration changes during pregnancy are limited, lacking established reference ranges.
  • Accurate interpretation of renal function markers is vital for maternal health, especially in conditions like pre-eclampsia.

Purpose of the Study:

  • To establish a reliable, cross-sectional reference interval for plasma creatinine concentrations throughout normal pregnancy.
  • To provide trimester-specific upper limits of normal for creatinine during gestation.
  • To inform clinical practice regarding the assessment of renal function in pregnant women.

Main Methods:

Related Experiment Videos

  • Analysis of a large cohort of women experiencing normal pregnancies.
  • Utilization of modern laboratory techniques for precise creatinine measurement.
  • Application of robust statistical methods to derive reference intervals.

    • Main Results:

    • The study determined trimester-specific upper limits for plasma creatinine: 85 µmol/l (first trimester), 80 µmol/l (second trimester), and 90 µmol/l (third trimester).
    • These upper limits are higher than previously suggested but remain significantly lower than non-pregnant values.
    • Demonstrated a clear need for pregnancy-specific creatinine reference ranges.

    Conclusions:

    • The established reference intervals provide essential data for the accurate clinical assessment of renal function in pregnant women.
    • These findings are particularly important for identifying renal abnormalities in conditions such as pre-eclampsia.
    • Updated reference ranges enhance the diagnostic capabilities for obstetric and nephrologic care during pregnancy.