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Updated: Aug 21, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
Published on: May 8, 2015
A modular approach to DNA-programmed self-assembly of macromolecular nanostructures
Kurt V Gothelf1, Raymond S Brown
1Department of Chemistry, University of Aarhus, Langelandsgade 140, 8000 Aarhus C, Denmark. kvg@chem.au.dk
Abstract:
DNA-programmed organic reactions are new and powerful tools for assembling chemical compounds into predetermined complex structures and a brief review of their use is given. This approach is particular efficient for the selection and covalent coupling of multiple components. DNA-templated synthesis is used for polymerization of PNA tetramers and for copying of the connectivity information in DNA. Direct DNA-programmed multicomponent coupling of custom designed organic modules is described. The macromolecular structures obtained are highly conjugated potentially conducting nanoscaffolds. Some future developments in this area are discussed.
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