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Updated: Aug 21, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Liquid chromatographic enantioseparation of aryl alpha-amino ketones on a crown ether-based chiral stationary phase
Myung Ho Hyun1, Guanghui Tan, Yoon Jae Cho
1Department of Chemistry, Pusan National University, Pusan 609-735, Republic of Korea. mhhyun@pusan.ac.kr
Abstract:
A liquid chromatographic chiral stationary phase based on (3,3'-diphenyl-1,1'-binaphthyl)-20-crown-6 covalently bonded to silica gel was applied in the resolution of aryl alpha-amino ketones including cathinone, the main psychoactive alkaloid found in the leaves of the khat plant. The resolution was excellent, the separation factors ranging between 1.72 and 8.58 and the resolution factors (R(S)) ranging between 2.60 and 11.10. The chromatographic resolution behaviour was dependent on the type and the content of organic and acidic modifiers and the ammonium acetate concentration in aqueous mobile phase and the column temperature.
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