[Use of antipsychotics in first line]

Today, antipsychotic drugs are widely used in the medical management of various psychiatric conditions. Although, the first generation neuroleptics have proved their efficacy in treating the positive psychotic symptoms of schizophrenia, their use has been associated with a variety of side effects including significant extrapyramidal symptoms. The newer antipsychotics offer many notable advantages compared with the older neuroleptics. Indeed, they are not only effective at treating positive psychotic symptoms but their use has also been associated with a positive clinical impact on negative symptoms of schizophrenia and their indication has also been extended to the management of bipolar disorder. Although, they do present a better side effects profile, some specific problems have been reported such as weight gain and increased risk for diabetes.