Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Asthma and cigarette smoking.

N C Thomson1, R Chaudhuri, E Livingston

  • 1Dept of Respiratory Medicine, Division of Immunology, Infection and Inflammation, Western Infirmary & University of Glasgow, Glasgow, G11 6NT, UK. n.c.thomson@clinmed.gla.ac.uk

The European Respiratory Journal
|November 2, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Health Services Research Agenda for Bariatric Surgery Within the Veterans Health Administration.

Journal of general internal medicine·2017
Same author

Synthesis and activity of the salicylic acid ester of bakuchiol in psoriasis-surrogate keratinocytes and skin substitutes.

Clinical and experimental dermatology·2017
Same author

Findings from a pilot Randomised trial of an Asthma Internet Self-management Intervention (RAISIN).

BMJ open·2016
Same author

Decreased FEV1 % in asthmatic adults in Scottish homes with high Environmental Relative Moldiness Index values.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2015
Same author

Response to Mroczkowski (2014): Lost in translation, or overestimating administrative data for outcome control in colorectal surgery.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2014
Same author

Novel therapies targeting eosinophilic inflammation in asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2014
Same journal

Beyond the 5th percentile: rethinking diagnostic thresholds in pulmonary function testing.

The European respiratory journal·2026
Same journal

A Transcriptomic Atlas of Chronic Lung Allograft Dysfunction.

The European respiratory journal·2026
Same journal

Risk of cancer and mortality in patients with interstitial lung diseases: Danish cohort study.

The European respiratory journal·2026
Same journal

Proposing a minimal important difference in NTproBNP in pulmonary arterial hypertension.

The European respiratory journal·2026
Same journal

Unlocking growth potential: Ivacaftor therapy and developmental gains in lung and height in a cohort study of children and young adults with cystic fibrosis.

The European respiratory journal·2026
Same journal

Decoding the Lymphangioleiomyomatosis (LAM) Niche Microenvironment <i>via</i> Integrative Analysis of Single Cell Multiomics and Spatial Transcriptomics.

The European respiratory journal·2026
See all related articles

Cigarette smoking worsens asthma symptoms and lung function decline. Asthmatic smokers show altered inflammation and corticosteroid resistance, necessitating smoking cessation or alternative therapies.

Area of Science:

  • Pulmonology
  • Respiratory Medicine
  • Clinical Immunology

Background:

  • Approximately 25% of adults with asthma are current cigarette smokers in developed countries.
  • Asthma and smoking synergistically lead to severe symptoms, accelerated lung function decline, and reduced corticosteroid effectiveness.
  • Limited data exists on airway pathology in smokers with asthma, with evidence suggesting mixed inflammatory responses.

Purpose of the Study:

  • To review the complex interactions between asthma and cigarette smoking.
  • To explore the mechanisms underlying corticosteroid resistance in asthmatic smokers.
  • To discuss the implications for asthma management and treatment.

Main Methods:

  • Literature review of studies investigating asthma, cigarette smoking, and airway inflammation.

Related Experiment Videos

  • Analysis of data on inflammatory cell phenotypes, glucocorticoid receptor expression, and transcription factor activity.
  • Synthesis of evidence regarding the effects of smoking on asthma control and therapeutic response.

    • Main Results:

    • Smokers with asthma exhibit heightened and suppressed inflammatory responses compared to non-smokers.
    • Mechanisms for corticosteroid resistance may include altered inflammatory cell profiles, changes in glucocorticoid receptor ratios, and dysregulated transcription factor activity.
    • Adverse effects of smoking on asthma control and treatment response are significant.

    Conclusions:

    • Smoking cessation is crucial for individuals with asthma.
    • Further research is needed to fully understand the impact of smoking cessation on reversing adverse effects.
    • Alternative or supplementary therapies are required for asthmatic smokers unable to quit inhaled corticosteroids.