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Published on: November 9, 2016
Usefulness of the serum electrolyte panel in the management of pediatric dehydration treated with intravenously
Joe E Wathen1, Todd MacKenzie, Joan P Bothner
1Department of Pediatrics, Section of Emergency Medicine, University of Colorado Health Sciences Center/Children's Hospital, Denver, Colorado, USA. wathen.joseph@tchden.org
Insights
Routine serum electrolyte panels (SEPs) in dehydrated children receiving intravenous fluids (IVFs) offer limited clinical management changes. While some abnormal SEP values are common, physicians often struggle to predict their significance, impacting treatment decisions.
Area of Science:
- Pediatric Emergency Medicine
- Clinical Pathology
- Laboratory Medicine
Background:
- Serum electrolyte panels (SEPs) are frequently ordered for pediatric patients with dehydration.
- The clinical utility of routine SEPs in managing dehydrated children receiving intravenous fluids (IVFs) remains largely unproven.
Purpose of the Study:
- To evaluate the usefulness of routinely ordered SEPs in the treatment of dehydrated pediatric patients receiving IVFs.
- To assess the impact of SEP results on clinical management decisions and patient outcomes.
Main Methods:
- Prospective study of children aged 2 months to 9 years with dehydration receiving IVFs in a pediatric emergency department.
- Data collected included historical information, physical examination, dehydration severity, and SEP results.
- Physicians documented predicted SEP importance, and outcomes included changes in management, dispositions, and unscheduled return visits (URVs).
Main Results:
- 182 patients were enrolled; 48% had at least one abnormal SEP value.
- Clinically significant findings included low bicarbonate (28%), hypoglycemia (9.9%), hypokalemia (6.0%), and hypernatremia (3.0%).
- SEP results altered clinical management in 10.4% of cases; physician prediction of clinical significance had 58% sensitivity.
Conclusions:
- Attending physicians were poor at predicting which children would have clinically significant SEP results.
- Low bicarbonate levels correlated with observation unit use but not hospitalization or URVs.
- SEPs can provide useful information for treating some dehydrated children receiving IVFs, particularly when guiding observation unit care.
Background:
The serum electrolyte panel (SEP) is a frequently ordered laboratory test, but it has unproven usefulness in the treatment of dehydrated pediatric patients. Our study purpose was to evaluate the usefulness of routinely ordering a SEP in the treatment of dehydrated pediatric patients receiving intravenous fluids (IVFs).
Methods:
Children 2 months to 9 years of age who were receiving IVFs because of dehydration were prospectively studied in a pediatric emergency department (PED). Historical data, physical examination findings, degree of dehydration, and SEP results were recorded. After patient evaluation, attending physicians documented whether they would have ordered a SEP. Outcome measurements included changes in clinical management on the basis of SEP results, as well as correlations of dispositions and unscheduled return visits (URVs) with SEP results.
Results:
A total of 182 patients were enrolled in the study. One hundred eleven patients had mild dehydration, 55 moderate dehydration, and 16 severe dehydration. Eighty-eight patients (48%; 95% confidence interval: 41-56%) had > or =1 abnormal SEP value. Clinically relevant findings included bicarbonate levels of <16 mmol/L for 28% of patients, hypoglycemia for 9.9%, hypokalemia for 6.0%, and hypernatremia for 3.0%. The attending physicians predicted that a SEP would be clinically important for 34% of all patients. There was a 58% sensitivity in detecting which children would have clinically significant SEP results. Overall, SEP results changed clinical management in 10.4% of cases. One hundred sixty-five (91%) of the patients were discharged from the PED (including 48 who were initially observed), of whom 7 (3.8%) had URVs to the PED within 72 hours and were given additional IVFs. Seventeen patients were admitted (median: 2.6 days), 2 of whom had URVs after hospital discharge for additional IVFs.
Conclusions:
On the basis of initial presentation, attending physicians were poor at predicting which children would have clinically significant SEP results. Low bicarbonate values were correlated with observation unit use but not with hospitalization or URVs. The observation unit provided effective care for a subset of dehydrated patients, avoiding the need for hospitalization. Obtaining a SEP can provide useful information for the treatment of some children receiving IVFs because of dehydration.
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