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[Cushing disease: long-term follow-up after transsphenoidal surgery]
Carlos A Benbassat1, Gloria Tsvetov, Daphna Shefet
1Endocrine Institute, Rabin Medical Center, Beilinson Campus, Sackler Faculty of Medicine, Tel Aviv University. carlosb@netvision.net.il
Harefuah
|November 4, 2004
Summary
Transsphenoidal surgery offers an effective treatment for Cushing disease, with a 70% cure rate. Experienced surgeons achieve high success, with pituitary surgery being the primary choice for ACTH-secreting tumors.
Area of Science:
- Endocrinology
- Neurosurgery
- Oncology
Context:
- Cushing disease, caused by ACTH-secreting pituitary tumors, presents significant health risks.
- Transsphenoidal surgery is the primary treatment, aiming for tumor removal.
- Postoperative hypocortisolemia is a key indicator of successful treatment.
Purpose:
- To evaluate the surgical outcomes and long-term follow-up of Cushing disease patients.
- To assess the effectiveness of transsphenoidal surgery for Cushing disease.
Summary:
- This study reviewed 27 patients with Cushing disease treated surgically between 1990 and 2003.
- The overall cure rate was 70%, reaching 80% for microadenomas.
- Experienced surgeons reported no major complications, with a low recurrence rate after a mean follow-up of 5.9 years.
Impact:
- Pituitary surgery is confirmed as an effective treatment for Cushing disease when performed by experienced neurosurgeons.
- The findings support surgical intervention as a primary therapeutic strategy.
- This research contributes to understanding the long-term efficacy of surgical management for Cushing disease.