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Updated: Aug 21, 2026
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Multiple subclinical syringomatous proliferations encountered during Mohs surgery for basal cell carcinoma
Snehal P Amin1, Alysa R Herman, Klaus J Busam
1Department of Dermatology, Presbyterian Hospital of Cornell University, New York, New York 10022, USA.
Background:
Examination of Mohs surgery frozen sections may lead to discovery of incidental benign neoplasms such as syringomas.
Objective:
An unusual occurrence of numerous subclinical syringomatous proliferations discovered during Mohs surgery for a basal cell carcinoma that posed a diagnostic and management dilemma is reported.
Methods:
Clinical records and histologic sections are examined.
Result:
Multiple syringomatous proliferations were noted around a basal cell carcinoma during Mohs surgery. A few foci were atypical appearing and focally extending into the deep dermis causing a diagnostic dilemma. All atypical syringomatous proliferations were excised. Evaluation of final Mohs margins by permanent sections and biopsies of normal-appearing facial skin showed multiple benign syringomas.
Conclusion:
Although solitary subclinical syringomas have been described in association with basal cell carcinomas, the occurrence of multiple syringomas and syringomatous proliferations has not been previously reported. Dermatologists should be aware of the existence of this phenomenon and consider permanent section evaluation to better determine nature of unusual incidental tumors identified in frozen sections during Mohs surgery.
