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Related Experiment Videos

The relationship between partial splenectomy and peripheral leukocyte count.

Hanna Bessler1, Michael Bergman, Hertzel Salman

  • 1The Laboratory for Immunology and Hematology Research, Rabin Medical Center-Golda Campus, Petah-Tiqva and the Sackler School of Medicine, Tel-Aviv University, Ramat-Aviv, Israel.

The Journal of Surgical Research
|November 4, 2004
PubMed
Summary
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Partial splenectomy in mice preserves normal peripheral white blood cell counts and immune response, unlike total splenectomy. A remaining spleen portion regulates white blood cell production and immune activity.

Area of Science:

  • Immunology
  • Surgical Pathology

Background:

  • Partial splenectomy preserves spleen function for hypersplenism treatment.
  • Total splenectomy often results in significant leukocytosis.
  • The study investigates spleen remnant function post-partial splenectomy.

Purpose of the Study:

  • To compare peripheral white blood cell counts (PWBC) after partial versus total splenectomy in mice.
  • To assess the immune response following partial and total splenectomy.

Main Methods:

  • Mice underwent 70% partial splenectomy, total splenectomy, sham operation, or served as controls.
  • Proliferative response of mononuclear cells to concanavalin A (Con A) was measured.

Main Results:

  • Partial splenectomy (70%) did not cause significant leukocytosis.

Related Experiment Videos

  • Mononuclear cell response to Con A was similar to controls in partially splenectomized mice.
  • Total splenectomy increased peripheral blood cell response but decreased peritoneal cell response to Con A.

    • Conclusions:

    • Spleen remnant after 70% partial splenectomy sufficiently maintains normal PWBC counts.
    • The spleen remnant plays a regulatory role in PWBC production.
    • Partial splenectomy preserves significant immune activity, indicated by normal Con A response.