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[Hereditary intermittant fever]

Gilles Grateau1, Brigitte Granel, Véronique Hentgen

  • 1Service de médecine interne, Hôtel-Dieu, Assistance publique-Hôpitaux de Paris. gilles.grateau@htd.ap-hop-paris.fr

Presse Medicale (Paris, France : 1983)
|November 4, 2004
PubMed
Abstract

Insights

Familial Mediterranean Fever (FMF) is not the only hereditary inflammatory disease. Four distinct conditions now exist, requiring precise diagnosis for effective management and treatment.

Area of Science:

  • Genetics and immunology of autoinflammatory diseases.

Context:

  • Familial Mediterranean Fever (FMF) is a well-known hereditary inflammatory disease.
  • Advances in genetic and clinical characterization have identified other related conditions.

Purpose:

  • To delineate hereditary inflammatory diseases beyond FMF.
  • To highlight the importance of accurate diagnosis for these conditions.

Summary:

  • Four hereditary diseases characterized by intermittent inflammatory flares are now recognized.
  • These include FMF, TNF receptor-associated periodic syndrome, hyperimmunoglobulinemia D syndrome, and the TRAPS-CINCA spectrum (including Muckle Wells syndrome and familial cold urticaria).

Impact:

  • Precise diagnosis is crucial for targeted management and treatment strategies.
  • Improved understanding aids in differentiating these distinct autoinflammatory disorders.

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