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[Oncogenic transcription factors as splicing regulators]

Orianne Théoleyre1, Faouzi Baklouti

  • 1Equipe épissage alternatif et différenciation cellulaire, Centre de Génétique moléculaire et cellulaire, CNRS UMR 5534, Université Lyon 1, Bâtiment Gregor Mendel, 16, rue R. Dubois, 69622 Villeurbanne, France.

Medecine Sciences : M/S
|November 5, 2004
PubMed

Insights

Oncogenic transcription factors can disrupt normal cell growth and may influence pre-messenger RNA (mRNA) splicing. Understanding these roles aids in developing targeted cancer therapies.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Genetics

Context:

  • Oncogenes regulate critical cellular processes, and their aberrant expression drives tumor formation.
  • Disregulated oncogenic transcription factors interfere with cell growth, differentiation, and survival pathways.
  • Emerging evidence links oncogene activity alterations to pre-messenger RNA (mRNA) splicing defects.

Purpose:

  • To review recent advances investigating the role of oncogenic transcription factors in pre-mRNA splicing regulation.
  • To explore the connection between oncogene-driven transcription and splicing processes.
  • To highlight the implications of oncogene alterations in cancer.

Summary:

  • Altered oncogene expression, through various genetic mechanisms, contributes to tumorigenesis.
  • Oncogenic transcription factors play a role in cellular regulatory cascades, impacting cell fate.
  • This review focuses on the intersection of oncogenes, transcription, and pre-mRNA splicing, particularly concerning RNA polymerase II.
  • Investigating the impact of oncogenic transcription factors on splicing offers new therapeutic avenues.

Impact:

  • Understanding oncogene-mediated splicing alterations has significant prognostic value.
  • Insights can guide the development of novel therapeutic strategies targeting cancer cell proliferation.
  • Therapeutic approaches may focus on promoting cell differentiation or apoptosis over uncontrolled growth.

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