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Published on: November 12, 2020
The outcome of pseudotumor cerebri induced by tetracycline therapy
A Kesler1, Y Goldhammer, A Hadayer
1Neuro-ophthalmology Unit, Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. kesler@netvision.net.il
Objective:
To demonstrate the association between tetracycline treatment and pseudotumor cerebri (PTC).
Methods:
Consecutive patients from two neuro-ophthalmic referral centers, who developed PTC syndrome post-treatment with tetracycline, were enrolled and followed for a minimum of 2 years after cessation of tetracycline.
Results:
A total of 243 consecutive patients were diagnosed with PTC; 18 had concurrent history of tetracycline treatment; a third experienced a limited course of illness with no relapses; 12 had a variable course with a prolonged relapsing illness. Mean duration of tetracycline treatment prior to diagnosis was 2.73 months.
Conclusions:
Tetracycline, and especially minocycline, is currently considered a cause or a precipitating factor for PTC. Although there is little information on the natural course of tetracycline induced PTC, the present cases demonstrate that drug withdrawal is curative only in some patients.
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