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HLA-DR B1 and DQ B1 polymorphisms in patients with coronary artery ectasia
Ramazan Akdemir1, Hakan Ozhan, Hüseyin Gunduz
1Abant Izzet Baysal University Düzce Faculty of Medicine Dept of Cardiology Konuralp Düzce, Turkey. rakdemir@yahoo.com
Insights
Certain human leukocyte antigen (HLA) class II gene polymorphisms, specifically HLA-DRB1*13, DR16, DQ2, and DQ5, are more common in patients with coronary artery ectasia (CAE). These findings suggest a potential role in CAE development.
Area of Science:
- Immunogenetics
- Cardiovascular Medicine
- Human Genetics
Background:
- Coronary artery ectasia (CAE) is a condition characterized by abnormal dilation of coronary arteries.
- The genetic factors contributing to CAE pathogenesis are not fully understood.
- Human leukocyte antigen (HLA) genes play a crucial role in immune responses and have been implicated in various diseases.
Purpose of the Study:
- To investigate the association between polymorphisms in HLA class II genes and the risk of developing coronary artery ectasia (CAE).
Main Methods:
- Genotyping of HLA class II alleles was performed in 26 patients diagnosed with CAE.
- A control group of 95 healthy individuals was included for comparison.
- Genotype frequencies were compared between the CAE patient group and the control group.
Main Results:
- Specific HLA class II genotypes, including HLA-DRB1*13, DR16, DQ2, and DQ5, were found to be significantly more prevalent in patients with CAE.
- No significant differences in traditional coronary heart disease risk factors were observed between patients with these genotypes and those without.
Conclusions:
- The identified HLA class II genotypes (HLA-DRB1*13, DR16, DQ2, and DQ5) may be associated with the underlying mechanisms of CAE.
- These genetic variations could potentially increase an individual's susceptibility to developing coronary artery ectasia.
Objectives:
The purpose of our study was to evaluate the significance of polymorphisms in HLA class II genes in coronary artery ectasia (CAE) patients.
Methods And Results:
Twenty-six patients with CAE without associated cardiac defects were enrolled in the study. CAE was defined as luminal dilation of 1.5- to 2.0-fold of normal limits. Ninety-five healthy subjects who were donors for different organ transplantations, were chosen as control group. Physical examination, electrocardiography and chest X-ray were completely normal in these cases. Both the patients and the control group were screened and compared for their HLA class II genotypes. HLA-DR B1*13, DR16, DQ2 and DQ5 genotypes were significantly more frequent in the patient group. When the known risk factors of coronary heart disease were compared in the patients carrying these genotypes with the non-carrying group, no significant differences were encountered.
Conclusions:
HLA-DR B1*13, DR16, DQ2 and DQ5 may be associated with the pathogenesis and increase the risk of CAE.
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