A case of biopsy-negative temporal arteritis--diagnostic challenges
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Updated: Jul 28, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
David van der Straaten1, Mariolyn Rajakulenthiran, Penny A McKelvie
1The Royal Victorian Eye & Ear Hospital, 32 Gisborne Street, East Melbourne, Victoria, 3002, Australia.
Abstract:
A patient with systemic symptoms but no visual loss was investigated for suspected giant cell arteritis. Initial temporal artery biopsy was reported as negative; however, she returned with visual loss 2 months later, and the diagnosis of giant cell arteritis was confirmed with a subsequent biopsy. In hindsight, signs suggestive of the disease were present in the original biopsy, although the usual diagnostic features were absent.
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