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Related Experiment Videos

A new origin for the maxillary jaw.

Sang-Hwy Lee1, Olivier Bédard, Marcela Buchtová

  • 1Department of Oral, Maxillofacial Surgery and Oral Science Research Center, Medical Science and Engineering Research Center, BK 21 Project for Medical Science, College of Dentistry Yonsei University, Seoul, Korea.

Developmental Biology
|November 9, 2004
PubMed
Summary
This summary is machine-generated.

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Craniofacial development reveals the maxillary prominence originates from post-optic mesenchyme, not the first pharyngeal arch. This finding redefines upper jaw formation and its evolutionary origins in amniotes.

Area of Science:

  • Developmental Biology
  • Craniofacial Development
  • Evolutionary Biology

Background:

  • The first pharyngeal arch is traditionally understood to form both maxillary and mandibular jaw components.
  • The precise origin of maxillary cells, whether from the first pharyngeal arch or a separate cranial condensation, remained uninvestigated.

Purpose of the Study:

  • To determine the embryonic origin of the maxillary prominence and its contribution to craniofacial structures.
  • To map cell fates within the pharyngeal arches and surrounding tissues during early craniofacial development.

Main Methods:

  • Fate mapping using dye injections (CM-DiI) in stage 13-17 and stage 24 chicken embryos.
  • Analysis of gene expression patterns, including retinoic acid receptor beta (Rarbeta) and bone morphogenetic protein 4 (Bmp4).

Related Experiment Videos

  • Grafting experiments of stage 24 maxillary prominences.

    • Main Results:

    • The maxillary prominence is primarily derived from post-optic mesenchyme, with minimal contribution from the maxillo-mandibular cleft.
    • Cells from the first pharyngeal arch exclusively contribute to the mandibular prominence.
    • Labeled cells formed maxillary, palatine, and jugal bones, but not the premaxilla or prenasal cartilage; cranial cells formed distal structures, caudal cells formed proximal ones.

    Conclusions:

    • The maxillary prominence and its skeletal derivatives originate from a distinct maxillary condensation, separate from the first pharyngeal arch.
    • Gene expression patterns (Rarbeta, Bmp4) differentiate cranial and caudal maxillary prominence regions.
    • Evolutionarily, the proximalization of the first pharyngeal arch-derived palatoquadrate cartilage may have facilitated the development of the bony upper jaw in amniotes.