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Updated: Aug 21, 2026

Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis
Published on: January 21, 2020
French experience of silicone tracheobronchial stenting in children
Michael Fayon1, Lionel Donato, Jacques de Blic
1Département de Pédiatrie, Hôpital Pellegrin-Enfants, Bordeaux, France. michael.fayon@chu-bordeaux.fr
Insights
Silicone stents offer a feasible treatment for pediatric airway disorders like tracheomalacia, with 43% success. Larger stents may prevent migration, a key failure point, improving outcomes for children.
Area of Science:
- Pediatric Pulmonology
- Biomaterials Science
- Medical Device Engineering
Background:
- Airway obstruction in children presents significant management challenges.
- Tracheal and bronchial stenting is an emerging therapeutic option for pediatric airway disorders.
- Silicone stents offer potential biocompatibility advantages over metal stents.
Purpose of the Study:
- To evaluate the feasibility and outcomes of silicone stent placement in pediatric patients.
- To identify factors contributing to the success or failure of silicone stents in airway management.
- To compare the performance of silicone stents with existing literature on metal stents.
Main Methods:
- Retrospective analysis of 14 pediatric patients (aged 2-69 months) who underwent tracheal or main-stem bronchial silicone stent insertion.
- Indications included tracheomalacia, airway kinking, vascular compression, and congenital tracheal stenosis.
- Outcomes assessed included technical success, clinical success, duration of stent placement, complications, and biocompatibility.
Main Results:
- Overall success rate was 43% (6/14), with the best outcomes in tracheomalacia.
- Stent migration was the primary cause of failure in 5 cases, suggesting a need for larger stent sizes.
- Complications were infrequent, including one case of stent obstruction; no wall erosion occurred. Silicone stents demonstrated good biocompatibility.
Conclusions:
- Silicone stent placement is a feasible therapeutic option for specific pediatric airway disorders.
- Optimizing stent size is crucial to improve stability and reduce migration-related failures.
- Further research is warranted to establish the long-term efficacy and safety of silicone stents in pediatric airway management.
Abstract:
Silicone stents were inserted into the trachea or left main-stem bronchus in 14 children aged 2-69 months (median, 7 months). Indications were as follows: tracheomalacia or airway kinking (7 cases), vascular compression (5 cases), and surgically corrected congenital tracheal stenoses (2 cases). The best results were obtained in tracheomalacia. Overall, 6 cases out of 14 (43%) were considered successful, with a stent placement duration of 3-15 months (median, 7 months). Two cases were considered a technical success, although they were clinical failures. Five cases were considered failures primarily due to stent migration. A retrospective analysis of failures suggests that most of these could have been avoided by the use of larger stents. One patient died of stent obstruction. No wall erosion was observed, and the development of granulation tissue was infrequent. Endoscopic removal of the prostheses was uneventful. The biocompatibility of silicone stents appears to be better than what is reported for metal ones, although the stability of the former is less satisfactory. The present study shows the feasibility of silicone stent placement in infants. These stents should be considered as a possible therapeutic option in certain types of childhood airway disorders, although further studies are required.
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