Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polio eradication in India: some observations.

Yash Paul1, Priya

  • 1A-D-7, Devi Marg, Bani Park, Jaipur 202016, India. dryashpaul2003@yahoo.com

Vaccine
|November 10, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating a nurse-led, audit-based antimicrobial stewardship in the medical emergency unit of a tertiary level hospital.

Infection control and hospital epidemiology·2026
Same author

A multifunctional polyketide synthase in nematodes produces divergent families of signaling molecules that control different developmental arrests.

bioRxiv : the preprint server for biology·2026
Same author

Prevalence and Risk Factors of Refractive Errors among School-aged Children in Postpandemic Eastern India: A Cross-sectional Study.

Annals of African medicine·2026
Same author

Real-world Impact of Antivascular Endothelial Growth Factor Treatment on Visual and Anatomical Outcomes in Diabetic Macular Edema: A Prospective Observational Study.

Annals of African medicine·2026
Same author

Selective Functionalization of 1-substituted-3-arylquinoxalin-2(1<i>H</i>)-ones <i>via</i> C-H activation.

RSC advances·2026
Same author

Selenium-catalyzed organic transformations.

iScience·2026

India

Area of Science:

  • Public Health
  • Vaccinology
  • Epidemiology

Background:

  • The World Health Organization aimed for global poliomyelitis eradication by 2000 via resolution WHA 41.28.
  • Despite extensive efforts, achieving a polio-free India remains a significant challenge.
  • Oral polio vaccine (OPV) has shown limited success in India, with high rates of vaccine failure and vaccine-associated paralytic polio (VAPP).

Purpose of the Study:

  • To investigate the reasons behind the high incidence of oral polio vaccine (OPV) failure in India.
  • To explore the contributing factors to the increasing cases of vaccine-associated paralytic polio (VAPP) in the country.

Main Methods:

  • This study critically reviews existing data and literature on polio eradication efforts in India.
  • Analysis focuses on vaccine efficacy, vaccine failure rates, and the occurrence of VAPP.

Related Experiment Videos

  • Investigates the impact of OPV administration, including to immunocompromised children, and the unavailability of inactivated polio vaccine (IPV).

    • Main Results:

    • Oral polio vaccine (OPV) has demonstrated a high incidence of failure in the Indian population.
    • A notable number of children have developed paralytic polio despite receiving multiple OPV doses.
    • Vaccine-associated paralytic polio (VAPP) cases are increasing, potentially exacerbated by vaccine failures and the use of OPV in immunocompromised individuals due to IPV unavailability.

    Conclusions:

    • The current strategy utilizing oral polio vaccine (OPV) is insufficient for polio eradication in India due to high vaccine failure rates.
    • Urgent research is needed to identify the specific causes of OPV failure and VAPP in India.
    • The findings underscore the need for alternative strategies or improved vaccine approaches to achieve polio eradication in India.