Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Toxic epidermal caused by lamotrigine.

Mike Sladden1, Neil Mortimer, Toby Chave

  • 1Department of Dermatology, Leicester Royal Infirmary, United Kingdom. m.sladden@doctors.org.uk

Australian Family Physician
|November 10, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Repair of a Large Lower Leg Defect.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2024
Same author

Repair of a Large Lateral Forehead and Temple Defect.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2022
Same author

How We Do It: Buried Cartilage Grafts to Assist in Autologous Skin Grafting.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2021
Same author

Refining the "Pin-Point Technique" for Pexing Sutures in Facial Reconstructive Surgery.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2019
Same author

Flexible razor blade for harvesting tumours in Mohs micrographic surgery.

The Australasian journal of dermatology·2015
Same author

Reconstruction of the upper lip.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2013
Same journal

Occupational violence and staff safety in general practice.

Australian family physician·2018
Same journal

You should get that mole checked out: Ethical and legal considerations of the unsolicited clinical opinion.

Australian family physician·2018
Same journal

Understanding the decision to commence a dose administration aid.

Australian family physician·2018
Same journal

Psychological distress and risky sexual behaviours among women aged 16-25 years in Victoria, Australia.

Australian family physician·2018
Same journal

A mixed-methods feasibility study of routinely weighing patients in general practice to aid weight management.

Australian family physician·2018
Same journal

The Australian Mid-West Coastal Marine Wound Infections Study.

Australian family physician·2018
See all related articles

Lamotrigine can cause severe skin reactions like toxic epidermal necrolysis (TEN), a rare but dangerous adverse drug effect. Careful dosing and monitoring are crucial when initiating lamotrigine treatment.

Area of Science:

  • Pharmacovigilance
  • Dermatology
  • Neurology

Background:

  • Lamotrigine use is increasing for epilepsy and mood stabilization.
  • It is considered for pregnant women with epilepsy.
  • General practitioners frequently prescribe lamotrigine.

Observation:

  • Two patients developed oral lesions and extensive rash after starting lamotrigine.
  • These reactions occurred shortly after treatment initiation.

Findings:

  • Lamotrigine can cause simple maculopapular rashes.
  • Rarely, severe mucocutaneous reactions, including toxic epidermal necrolysis (TEN), can occur.
  • TEN is a potentially fatal adverse mucocutaneous drug reaction.

Implications:

Related Experiment Videos

  • Early recognition of lamotrigine-induced skin reactions is vital.
  • Minimizing risk involves slow dose titration and avoiding concurrent sodium valproate.
  • Awareness of TEN risk is crucial for safe lamotrigine prescribing.