Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mapping dopamine D2/D3 receptor function using pharmacological magnetic resonance imaging.

Yin-Ching I Chen1, Ji-Kyung Choi, Susan L Andersen

  • 1Athinoula A. Martinos Center for Biomedical Imaging and MGH-NMR Center, Department of Radiology Massachusetts General Hospital, Charlestown, MA 02129, USA.

Psychopharmacology
|November 13, 2004
PubMed
Summary

Pharmacological MRI (phMRI) can non-invasively map dopamine D2/D3 autoreceptor (DAR) function. This study shows phMRI effectively detects how D2 receptor antagonists and agonists modulate dopamine release, mirroring invasive microdialysis results.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

fMRI Using GRAPPA EPI with High Spatial Resolution Improves BOLD Signal Detection at 3T.

The open magnetic resonance reviews·2026
Same author

Mapping subarachnoid cerebrospinal fluid circulation in the human brain.

bioRxiv : the preprint server for biology·2026
Same author

Neural activity drives directional subarachnoid cerebrospinal fluid flow in the human brain.

bioRxiv : the preprint server for biology·2026
Same author

TRACED: In vivo imaging of extracellular intrinsic diffusivity, tortuosity, cell size distribution and cell density in human glioma patients.

ArXiv·2026
Same author

BOLD fMRI reflects both vascular and metabolic signals.

Nature neuroscience·2026
Same author

Direct Reconstruction of DC Cortical Conductivity from Large-Scale Electron Microscopy Data.

bioRxiv : the preprint server for biology·2026

Area of Science:

  • Neuroscience
  • Pharmacology
  • Medical Imaging

Background:

  • Dopamine (DA) D2/D3 autoreceptors (DARs) regulate dopamine release and synthesis.
  • In vivo mapping of DAR function is challenging, often requiring invasive methods like microdialysis.
  • Pharmacological magnetic resonance imaging (phMRI) offers a potential non-invasive alternative.

Purpose of the Study:

  • To demonstrate phMRI's utility in mapping DAR function.
  • To show that amphetamine-induced relative cerebral blood volume (rCBV) changes can be modulated by D2 receptor antagonists and agonists.
  • To compare phMRI findings with invasive microdialysis measurements of DA release.

Main Methods:

  • Utilized phMRI with iron oxide contrast agents to map rCBV changes.
  • Administered amphetamine challenge post-treatment with varying doses of D2 antagonist eticlopride and D2 agonist quinpirole.

Related Experiment Videos

  • Compared phMRI-assessed D2 antagonism effects with microdialysis measurements of DA release.

    • Main Results:

    • Eticlopride (D2 antagonist) dose-dependently potentiated amphetamine-induced rCBV changes in the nucleus accumbens and caudate putamen.
    • Amphetamine-induced rCBV increase in the accumbens with eticlopride mirrored microdialysis-measured DA release.
    • Quinpirole (D2 agonist) reduced amphetamine-induced rCBV changes in the caudate putamen and nucleus accumbens.
    • Both drugs showed the largest effects in the nucleus accumbens.

    Conclusions:

    • phMRI can effectively map dopamine D2/D3 autoreceptor function non-invasively.
    • phMRI findings correlate with invasive microdialysis measurements.
    • This technique allows simultaneous mapping of DAR function across multiple brain regions.