Related Experiment Video
Updated: Aug 21, 2026

Purification of HLA-G+ Extravillous Trophoblasts from Human Term Placental Tissues for Phenotyping and Functional Analysis
Published on: March 13, 2026
[The significance of HLA-G for miscarriages]
Maciej Grzywacz1, Elzbieta Ronin-Walknowska
1Szpital Wojewódzki w Zielonej Górze.
Abstract:
In the article, we described major histocompatibility antigens and their distribution in the feto-maternal junction. In particular we have taken into consideration HLA-G, its structure and isoforms. Further on, we cited opinions about their role during reproductive processes, creation of syncytiotrophoblast, remodeling of spiral arteries, growing and maturation of placenta. The lack of correct function of HLA-G can lead to disorders in ovum implantation, hormonal and nutritional function of placenta which can cause reproductive failure, including abortions, intrautrine growth retardation, intrauterine fetal demise, preeclampsia. The genotype HLA-G is potentially related to habitual abortions.
More Related Videos
05:16Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
07:46Platform for Quantitative Detection of Endometrial Immune Cells Based on Immunohistochemistry and Digital Image Analysis
Published on: October 13, 2023
Related Concept Videos
Tissue Transplantation
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Teratogenicity
Transcytosis of IgG
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Lethal Alleles
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...