Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone fragility and collagen cross-links.

Eleftherios P Paschalis1, Elizabeth Shane, George Lyritis

  • 1Mineralized Tissue Division, Hospital for Special Surgery, New York, New York, USA.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|November 13, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Postpartum timing of teriparatide initiation and BMD response in pregnancy- and lactation-associated osteoporosis: an observational study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same author

Prevalence of Vitamin D Deficiency in Patients Admitted With Recent Fragility Hip Fracture: A Single-Center Retrospective Study.

Cureus·2025
Same author

Bone density and remodeling after discontinuation of sequential therapy for premenopausal idiopathic osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2025
Same author

Genetic contributors to osteoporosis in pregnancy and lactation associated osteoporosis (PLO).

Bone·2025
Same author

Increased Osteocyte Lacunae Size and Organic Matrix Pyridinoline Content in Transiliac Bone from Patients with Axial Spondyloarthritis (axSpA).

Calcified tissue international·2025
Same author

Elderly Caribbean Hispanic men have lower tibial stiffness and failure load compared to non-Hispanic White and Black men.

JBMR plus·2025

Collagen cross-link distribution differs significantly in fragile bone, impacting fracture risk. Infrared imaging reveals distinct patterns in osteoporotic patients compared to healthy individuals.

Area of Science:

  • Biomaterials Science
  • Orthopedics
  • Biochemistry

Background:

  • Bone fragility and fracture risk are influenced by bone mineral content and quality.
  • Collagen quality, a key bone component, is less understood in the context of bone fragility.

Purpose of the Study:

  • To investigate collagen cross-link distribution in the trabecular bone of patients with fragile bone.
  • To compare collagen cross-link patterns in osteoporotic and fractured bone with normal bone.

Main Methods:

  • Fourier transform infrared imaging (FTIRI) was used to analyze human iliac crest biopsy specimens.
  • The ratio of nonreducible to reducible collagen cross-links was quantified in bone-forming trabecular surfaces.
  • Specimens from osteoporotic patients and young women with spontaneous fractures were compared to normal subjects.

Related Experiment Videos

Main Results:

  • Significant differences were observed in the spatial variation of collagen cross-links between fragile and normal bone.
  • The distribution of collagen cross-links within the initial 50 micrometers of forming trabecular surfaces was markedly different in patients with fragile bone.

Conclusions:

  • Collagen cross-link patterns are distinct in individuals with fragile bone.
  • These findings highlight the importance of collagen quality in understanding bone fragility and fracture risk.