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Bladder cancer as a prognostic factor for upper tract transitional cell carcinoma
Michael Mullerad1, Paul Russo, Dragan Golijanin
1Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
The Journal of Urology
|November 13, 2004
Summary
A history of bladder transitional cell carcinoma (BTCC) significantly impacts upper tract transitional cell carcinoma (UTTCC) survival. Previous BTCC, whether superficial or invasive, worsens prognosis independently of UTTCC stage.
Area of Science:
- Urology
- Oncology
Background:
- Upper tract transitional cell carcinoma (UTTCC) is a rare malignancy with variable survival rates.
- Prognostic factors for UTTCC require further elucidation.
Purpose of the Study:
- To identify predictors of disease recurrence and survival in patients with UTTCC.
- To assess the impact of a history of bladder transitional cell carcinoma (BTCC) on UTTCC outcomes.
Main Methods:
- Retrospective analysis of 129 patients undergoing nephroureterectomy for UTTCC.
- Evaluation of prognostic factors including primary tumor stage, grade, and history of BTCC.
- Kaplan-Meier and Cox regression analyses for survival and recurrence.
Main Results:
- A history of BTCC was significantly associated with disease-specific survival (p=0.018).
- Primary disease stage also predicted survival (p=0.001).
- Patients with a history of BTCC showed distinct survival and bladder recurrence patterns.
Conclusions:
- A history of superficial or invasive BTCC adversely affects UTTCC prognosis.
- This adverse effect is independent of the primary UTTCC tumor stage.