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Updated: Aug 21, 2026

Assessment of Sexual Behavior of Male Mice
Published on: March 5, 2020
A 7-year experience of genetic males with severe phallic inadequacy assigned female
William G Reiner1, Bradley P Kropp
1Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA. william-reiner@ouhsc.edu
Insights
Males with severe phallic inadequacy assigned female at birth often identify as male, demonstrating functional psychosocial development. Those who do not convert to male may experience less successful outcomes.
Area of Science:
- Pediatric endocrinology
- Genetics
- Psychology
Background:
- Clinical decisions for sex assignment in male neonates with severe phallic inadequacy are complex.
- Understanding long-term outcomes is crucial for guiding these decisions.
Purpose of the Study:
- To examine the hypotheses behind assigning female gender at birth to male neonates with severe phallic inadequacy.
- To assess the psychosocial and sexual development of these individuals.
Main Methods:
- A longitudinal study of 18 genetic males with severe phallic inadequacy.
- Included diagnoses such as cloacal exstrophy, partial androgen resistance, mixed gonadal dysgenesis, and penile agenesis.
- Assessed physical, social, psychological, and sexual identity development, with initial sex assignment being female in 15 and male in 3.
Main Results:
- All patients exhibited male-typical behaviors and interests.
- Of 15 female-assigned patients, 10 eventually lived as males, with 6 living as females.
- Older patients living as males demonstrated more independent psychosocial development and successful romantic relationships compared to those living as females.
Conclusions:
- Males with severe phallic inadequacy, whether raised male or converted to male after female assignment, can achieve functional psychosocial development.
- Individuals assigned female at birth have a significant likelihood of identifying as male.
- Those not converting to male may face more challenging psychosocial developmental trajectories.
Purpose:
We examine the hypotheses underlying the clinical decision to assign female gender at birth in male neonates with severe phallic inadequacy.
Materials And Methods:
A total of 18 genetic males with severe phallic inadequacy were assessed longitudinally for physical, social, psychological and sexual identity development. Diagnoses included cloacal (11) and classic (1) exstrophy, partial androgen resistance (3), mixed gonadal dysgenesis (2) and penile agenesis (1). Neonatal sex assignment was female in 15 and male in 3 patients.
Results:
All patients demonstrated marked male typical behaviors and interests. Of the 15 female assigned patients 1 died, 1 refused to declare sexual identity or orientation, 1 converted to male before initial evaluation, 1 was reassigned male by the parents and 5 others declared male sexual identity. Thus, of 17 living patients 10 live as males and 6 as females. Of patients 17 years or older only those living as male lived independently. The 4 oldest patients living as male but only 1 patient living as female would discuss sexual orientation-all 5 declared orientation toward females, and 3 of these 4 males had girlfriends or were married. The sexually undeclared patient lived in a residential treatment center because of major behavioral difficulties since age 15. Only patients living as male had dated.
Conclusions:
This longitudinal study implies that males with severe phallic inadequacy reared male and those reared female but converting to male can have functional psychosocial developmental trajectories. Those reared female have a realistic likelihood of recognizing male sexual identity and converting to male. Those not converting to male appear to have less successful psychosocial developmental trajectories.
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