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Increased bladder permeability in interstitial cystitis/painful bladder syndrome.

Robert E Hurst1, Beverley Greenwood-Van Meerveld2, Amy B Wisniewski3

  • 1Department of Urology, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104; Department of Biochemistry and Molecular Biology, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104; Oklahoma Center for Neurosciences, College of Medicine, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104.

Translational Andrology and Urology
|January 12, 2016
PubMed
Summary

Interstitial cystitis (IC), also known as painful bladder syndrome (PBS), may stem from increased bladder permeability. This review explores its role in IC/PBS symptoms and treatment, suggesting a systemic disorder connection.

Keywords:
AnimalCystitisInterstitialIrritable Bowel SyndromeModelsPermeabilityUrinary bladder

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Area of Science:

  • Urology
  • Gastroenterology
  • Immunology

Background:

  • Interstitial cystitis (IC) definition evolved from Hunner's ulcer to a clinical diagnosis of exclusion, termed painful bladder syndrome (PBS).
  • The etiology of IC/PBS remains unknown, but a common theme involves increased bladder permeability.
  • Emerging research highlights cross-communication between visceral organs, suggesting a systemic basis for IC/PBS.

Purpose of the Study:

  • To review evidence linking increased bladder permeability to IC/PBS symptoms and treatment.
  • To explore the concept of IC/PBS as a systemic disorder involving interconnected bodily systems.

Main Methods:

  • Literature review of studies on bladder permeability in IC/PBS.
  • Review of research on visceral organ cross-communication.

Main Results:

  • Evidence suggests increased bladder permeability is significant in IC/PBS symptom development.
  • Increased permeability may be a key factor in therapeutic strategies for IC/PBS.
  • Interconnectedness of bladder, bowel, nervous system, and immune cells provides a framework for understanding IC/PBS.

Conclusions:

  • Increased bladder permeability is a critical factor in interstitial cystitis/painful bladder syndrome.
  • IC/PBS may be understood as a systemic condition due to complex inter-organ communication.
  • Further research into systemic interactions is crucial for effective IC/PBS management.