Fundamentals of Neurogastroenterology: Basic Science.
Beverley Greenwood-Van Meerveld1, Gary M Mawe2, Arthur Beyder3
1Department of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Gastroenterology
|April 24, 2026
Summary
This review summarizes advances in neurogastroenterology, focusing on disorders of gut-brain interaction (DGBI). It explores complex mechanisms and novel therapeutic strategies for improved patient care.
Area of Science:
- Neurogastroenterology
- Gut-Brain Axis Research
- Gastrointestinal Disorders
Background:
- Major advances in neurogastroenterology since the Rome IV criteria.
- Comprehensive review of physiological and pathophysiological mechanisms in disorders of gut-brain interaction (DGBI).
- DGBI are multifactorial, involving complex interactions between gut and brain systems.
Purpose of the Study:
- To highlight key studies and cutting-edge technologies in neurogastroenterology.
- To deepen the understanding of the neurobiology and neuroimmune function in DGBI.
- To explore novel therapeutic strategies for DGBI based on recent scientific advances.
Main Methods:
- Review of pivotal studies and expert consensus.
- Exploration of advanced technologies in the field.
- Analysis of risk factors and neurobiological underpinnings of DGBI.
Main Results:
- Enhanced understanding of brain-gut interactions and the enteric nervous system.
- Identification of microbiome influences and neuroimmune function in DGBI.
- Serotonergic signaling as a framework for linking symptoms and pathophysiology.
Conclusions:
- Scientific advances are improving the understanding of DGBI.
- Novel therapeutic strategies are emerging for better patient outcomes.
- Continued research in neurogastroenterology is crucial for advancing patient care.
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