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Updated: Aug 8, 2026

An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules
Published on: November 4, 2022
[Effect of ultra-fine powder technique on dissolution rates of andrographolide and dehydroandrographolide in
Rong-Li Qiu1, Lin Li, Xiang Li
1Department of Medicinal Chemistry, School of Pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China. rongliq@hotmail.com
Objective:
To investigate the effects of ultra-fine powder technique on dissolution rates of the components in Andrographis paniculata.
Methods:
High performance liquid chromatography was employed to determine the concentration of andrographolide and dehydroandrographolide in common powdered or ultra-fine powdered Andrographis paniculata.
Results:
The dissolution rates of andrographolide and dehydroandrographolide in ultra-fine powdered Andrographis paniculata were higher than those of the general powder.
Conclusion:
Ultra-fine powder technique promotes the dissolution rates of andrographolide and dehydroandrographolide.
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