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Updated: Aug 21, 2026

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
Published on: May 27, 2022
Long-term intracerebral inflammatory response after traumatic brain injury
S M Gentleman1, P D Leclercq, L Moyes
1Department of Neuropathology, Division of Neuroscience and Psychological Medicine, Imperial College London, Charing Cross Campus, London, UK. s.gentleman@imperial.ac.uk <s.gentleman@imperial.ac.uk>
Abstract:
Epidemiological and pathological studies suggest that head injury is a significant risk factor for subsequent neurodegeneration and cognitive decline in later life. The precise mechanisms for the development of post-traumatic neurodegenerative change are unclear but we hypothesize that persistence of inflammatory processes in the brain may play a key role and that some individuals are more susceptible to such changes based on their genetic make-up. In support of this hypothesis we present evidence of persistent elevated microglial activity in long-term survivors of head injury and the suggestion of an association between the extent of this activity and interleukin-1 genotype.
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