Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonpolymeric hydrogelator derived from N-(4-pyridyl)isonicotinamide.

D Krishna Kumar1, D Amilan Jose, Parthasarathi Dastidar

  • 1Analytical Science Discipline, Central Salt & Marine Chemicals Research Institute, G. B. Marg, Bhavnagar-364 002, Gujarat, India.

Langmuir : the ACS Journal of Surfaces and Colloids
|November 17, 2004
PubMed
Summary

N-(4-pyridyl)isonicotinamide is an effective hydrogelator, forming hydrogels across a broad concentration range. Other synthesized pyridyl amides did not exhibit gelation properties, highlighting the specific efficacy of this compound.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sequence-Defined Short Peptide-Derived Coacervate Vesicles for Targeted Therapeutics.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Supramolecular Integration of 18-Crown-6 and an N-Capped Short Peptide Enables Multivalent Recognition and Modulation of Amyloid-β Proteotoxicity.

Journal of the American Chemical Society·2026
Same author

Thiophene-Engineered Lipid II Recognition Enables Potent Membranolytic Eradication of MRSA.

Angewandte Chemie (International ed. in English)·2026
Same author

Supramolecular Synthon Strategy via Organic Salt Formation for Developing Topical Gel From Rhein: Synthesis, Gelation, Crystal Structures, and Antibacterial Properties Against MRSA.

Chemistry, an Asian journal·2026
Same author

Pyrene-Based Aggregation-Induced Emissive Manganese Carbonyl Complex for Green Light-Controlled Carbon Monoxide (CO) Release and Theranostic Applications.

Inorganic chemistry·2026
Same author

Supramolecular Nanoassemblies Harness Radical Excited-State Cascade Electron Transfer for Selective CO<sub>2</sub> Photoreduction.

Small (Weinheim an der Bergstrasse, Germany)·2026

Area of Science:

  • Supramolecular Chemistry
  • Materials Science

Background:

  • Pyridyl amides are a class of compounds with potential applications in materials science.
  • Hydrogelators are molecules capable of forming three-dimensional networks in water.

Purpose of the Study:

  • To synthesize and evaluate a series of pyridyl amides derived from isonicotinic acid, nicotinic acid, and benzoic acid for their hydrogelation properties.
  • To identify efficient hydrogelators among the synthesized compounds.

Main Methods:

  • Synthesis of pyridyl amide derivatives.
  • Gelation studies to determine minimum gelator concentration.
  • Characterization of hydrogels using Fourier transform infrared spectroscopy, variable temperature 1H NMR, single-crystal diffraction, X-ray powder diffraction (XRPD), and scanning electron microscopy.

Related Experiment Videos

Main Results:

  • N-(4-pyridyl)isonicotinamide (1) was identified as an efficient hydrogelator with a minimum gelator concentration of 0.37 wt %.
  • Hydrogels could be formed using N-(4-pyridyl)isonicotinamide over a wide concentration range (0.37-20 wt %).
  • The other synthesized amides (2-7) did not exhibit gelation properties.

Conclusions:

  • N-(4-pyridyl)isonicotinamide is a potent hydrogelator.
  • The molecular morphology (morph) responsible for gel formation differs between the hydrogel and its bulk solid/xerogel states, as indicated by diffraction studies.