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Metabolic syndrome targets.

Steven R Smith1

  • 1Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA. smithsr@pbrc.edu

Current Drug Targets. CNS and Neurological Disorders
|November 17, 2004
PubMed
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Metabolic syndrome, a marker for cardiovascular disease and diabetes risk, stems from energy excess. Addressing obesity and exploring peripheral targets like ectopic fat and inflammation can reverse its clinical features.

Area of Science:

  • Metabolic Disorders
  • Cardiovascular Disease Risk
  • Obesity Research

Background:

  • Metabolic syndrome is a cluster of clinical phenotypes indicating increased risk for cardiovascular disease (CVD) and diabetes.
  • Its core pathophysiology is linked to energy excess, making obesity a key factor.
  • Hypertension is excluded from this discussion.

Purpose of the Study:

  • To review recent developments in the pathophysiology of metabolic syndrome.
  • To concentrate on peripheral targets for potential therapeutic strategies.
  • To discuss the advantages and pitfalls of these targets.

Main Methods:

  • Review of recent literature on metabolic syndrome pathophysiology.
  • Focus on peripheral targets including ectopic fat, fat oxidation, substrate switching, mitochondrial biogenesis, lipolysis, lipid turnover, adipose tissue endocrine function, nutrient/energy sensing, and inflammation.

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  • Critical discussion of target advantages and pitfalls.

    • Main Results:

    • Energy excess is central to metabolic syndrome.
    • Peripheral targets offer potential strategies for reversing metabolic syndrome features.
    • Specific targets include ectopic fat, mitochondrial function, and inflammatory pathways.

    Conclusions:

    • Treating obesity is a primary strategy to reverse metabolic syndrome.
    • Peripheral targets require further investigation for therapeutic efficacy.
    • Understanding these targets is crucial for managing metabolic syndrome and associated risks.