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Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Related Experiment Video

Updated: Jun 23, 2026

Generation of Induced Regulatory T Cells from Primary Human Na&iuml;ve and Memory T Cells
14:23

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

Tregs and transplantation tolerance.

Patrick T Walsh1, Devon K Taylor, Laurence A Turka

  • 1Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6144, USA.

The Journal of Clinical Investigation
|November 17, 2004
PubMed
Summary
This summary is machine-generated.

Achieving immune tolerance to transplanted organs involves active, T cell-mediated processes. Regulatory T cell (Treg) subsets are key to preventing graft rejection and offer therapeutic potential.

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Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
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Related Experiment Videos

Last Updated: Jun 23, 2026

Generation of Induced Regulatory T Cells from Primary Human Na&iuml;ve and Memory T Cells
14:23

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
15:33

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Area of Science:

  • Immunology
  • Transplantation Biology
  • Cellular and Molecular Medicine

Background:

  • Graft rejection is a major hurdle in organ transplantation.
  • Immune tolerance, similar to self-tolerance, is crucial for successful transplantation.
  • Active immunoregulation, particularly T cell-mediated, prevents rejection of donor antigens.

Purpose of the Study:

  • To review the current understanding of regulatory T cell (Treg) subsets in allotolerance.
  • To elucidate the mechanisms by which Tregs prevent graft rejection.
  • To explore the therapeutic potential of Tregs in transplantation.

Main Methods:

  • Literature review of immunological mechanisms in allotolerance.
  • Analysis of T cell-mediated regulatory pathways.
  • Examination of Treg subsets and their functions.

Main Results:

  • Allotransplantation tolerance requires active, cooperative immune mechanisms.
  • Regulatory T cells (Tregs) play a central role in inducing and maintaining specific unresponsiveness to donor antigens.
  • Various Treg subsets employ distinct mechanisms to suppress immune responses against transplanted tissues.

Conclusions:

  • Immune tolerance to transplanted tissues is an active, regulated process.
  • Specific Treg subsets are critical effectors of allotolerance.
  • Harnessing Treg function holds significant promise for future transplantation therapies.